Protein Details: Potassium voltage-gated channel subfamily V member 1

Protein ID

ICDB_Pro_0719

Protein Name

Potassium voltage-gated channel subfamily V member 1

Gene Name

Kcnv1

Organism

Rattus norvegicus (Rat)

Length

503 amino acids

AlphaFoldDB

AF-P97557-F1-model_v4.pdb

Function

Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1; KCNB2; KCNC4 and KCND1; possibly by trapping them in intracellular membranes (By similarity)

Sequence

MDLSPRNRPLLDSSSLDSGSLTSLDSSVFCSEGEGEPLALGDCLTVNVGGSRFVLSQQALSCFPHTRLGKLAVVVASYRRLGALAAAPSPLELCDDANPVDNEYFFDRSSQAFRYVLHYYRTGRLHVMEQLCALSFLQEIQYWGIDELSIDSCCRDRYFRRKELSETLDFKKDTDDQESQHESEQDFSQGPCPTVRQKLWDILEKPGSSTAARIFGVISIIFVAVSIVNMALMSAELSWLNLQLLEILEYVCISWFTGEFILRFLCVKDRCHFLRKVPNIIDLLAILPFYITLLVESLSGSHTTQELENVGRLVQVLRLLRALRMLKLGRHSTGLRSLGMTITQCYEEVGLLLLFLSVGISIFSTIEYFAEQSIPDTTFTSVPCAWWWATTSMTTVGYGDIRPDTTTGKIVAFMCILSGILVLALPIAIINDRFSACYFTLKLKEAAVRQREALKKLTKNIATDSYISVNLRDIYARSIMEMLRLKGRERASTRSSGGDDFWF

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Detected in brain; in neocortex; olfactory tubercle; hippocampus; dentate gyrus; piriform cortex and amygdala. Detected in Purkinje cells and granular cells of the cerebellum; in hippocampal CA4 neurons and neocortex pyramidal cells.

DOI ID

10.1523/jneurosci.17-12-04652.1997

RefSeq

NP_067729.1